Endocrine Abstracts

Introduction: In small intestinal neuroendocrine tumors (SI-NET), unphysiological exposure to serotonin is considered as a major pathogenic factor predisposing to the development carcinoid heart disease (CHD), a complication of carcinoid syndrome associated with poor prognosis. The ability of biomarkers to predict the development of CHD is limited. The aim of our prospective study was to assess risk factors of CHD development and mortality in SI-NET.Meth...

Introduction: In multiple endocrine neoplasia 1 (MEN1), the decreased life expectancy is related especially to pancreatic neuroendocrine tumors (panNETs). Timely diagnosis of potentially aggressive panNETs is the cornerstone of the follow-up in MEN1. Somatostatin receptor positron emission tomography (SSTR PET/CT) has a high accuracy in the detection of neuroendocrine tumors. The role of this imaging modality in early diagnosis and follow-up of MEN1-related panNETs is unclear....

Background: Adrenal cortical carcinoma (ACC) is a rare malignancy known to be highly aggressive, with few specific treatment options. The objective was to evaluate clinicopathological features and outcome in patients treated at Helsinki University HospitalMethods and patients: We included all patients diagnosed with adrenocortical carcinoma (Weiss score ≥4) at Helsinki University Hospital during the years 2002 through 2017. Patients were identified...

Background20–30% of patients with metastatic small intestine neuroendocrine tumours (SI-NETs) suffer from carcinoid syndrome (CS), i.e. diarrhea, flushing, and bronchospasm. Of these, 25–50% develop carcinoid heart disease (CHD) characterized by valve fibrosis and right heart failure. There are no early predictive markers of CHD, which typically is diagnosed in the advanced stage.Aims of the studyTo...